Patients recently treated for B-lymphoid malignancies show increased risk of severe COVID-19: a CCC19 registry analysisImpact of B-cell malignancy therapy on COVID-19 outcomes
Patients with B-lymphoid malignancies have been consistently identified as a population at high risk of severe COVID-19. Whether this is exclusively due to cancer-related deficits in humoral and cellular immunity, or whether risk of severe COVID-19 is increased by anticancer therapy, is uncertain. Using data derived from the COVID-19 and Cancer Consortium (CCC19), we show that patients treated for B-lymphoid malignancies have an increased risk of severe COVID-19 compared with control populations of patients with non-B-lymphoid malignancies. Among patients with B-lymphoid malignancies, those who received anticancer therapy within 12 months of COVID-19 diagnosis experienced increased COVID-19 severity compared with patients with non-recently treated B-lymphoid malignancies, after adjustment for cancer status and several other prognostic factors. Our findings suggest that patients recently treated for a B-lymphoid malignancy are at uniquely high risk for severe COVID-19. SIGNIFICANCE: Our study suggests that recent therapy for a B-lymphoid malignancy is an independent risk factor for COVID-19 severity. These findings provide rationale to develop mitigation strategies targeted at the uniquely high-risk population of patients with recently treated B-lymphoid malignancies.
Authors
- Gayathri Nagaraj (ORCID: https://orcid.org/0000-0002-7586-6920)
- Chris Labaki (ORCID: https://orcid.org/0000-0002-9584-8455)
- Ryan C. Lynch (ORCID: https://orcid.org/0000-0001-6703-0894)
- Anup Kasi (ORCID: https://orcid.org/0000-0002-4305-5701)
- R. Alejandro Sica (ORCID: https://orcid.org/0000-0001-8877-4470)
- Shilpa Gupta (ORCID: https://orcid.org/0000-0002-8775-503X)
- Devendra Kc
- Tahir Latif (ORCID: https://orcid.org/0000-0002-4836-8627)
- Taylor K. Nonato
- Leyre Zubiri (ORCID: https://orcid.org/0000-0003-4226-7443)
- Andrew J. Portuguese (ORCID: https://orcid.org/0000-0003-1010-4578)
- Cecilia A. Castellano (ORCID: https://orcid.org/0000-0002-3775-9737)
- Monika Joshi (ORCID: https://orcid.org/0000-0003-4286-8492)
- Ziad Bakouny (ORCID: https://orcid.org/0000-0003-1906-5704)
- Michael Thompson (ORCID: https://orcid.org/0000-0002-8454-6603)
- Pedram Razavi (ORCID: https://orcid.org/0000-0003-4236-0576)
- Vadim S. Koshkin (ORCID: https://orcid.org/0000-0003-2277-8668)
- Joy Awosika (ORCID: https://orcid.org/0000-0001-6074-4771)
- Chih–Yuan Hsu (ORCID: https://orcid.org/0000-0001-8325-2112)
- Ruben A. Mesa (ORCID: https://orcid.org/0000-0001-5880-7972)
- Nathalie A. Johnson (ORCID: https://orcid.org/0000-0002-3211-9722)
- Aditi Shastri (ORCID: https://orcid.org/0000-0002-5366-8288)
- Nicole M. Kuderer (ORCID: https://orcid.org/0000-0002-9263-8540)
- Dimpy P. Shah (ORCID: https://orcid.org/0000-0001-9019-8310)
- Alicia Beeghly‐Fadiel (ORCID: https://orcid.org/0000-0001-9913-732X)
- Jeremy L. Warner (ORCID: https://orcid.org/0000-0002-2851-7242)
- Clara Hwang (ORCID: https://orcid.org/0000-0002-0998-323X)
- Jacob C. Cogan (ORCID: https://orcid.org/0000-0003-4036-7838)
- Mehmet Asım Bilen (ORCID: https://orcid.org/0000-0003-4003-1103)
- Elizabeth J. Klein (ORCID: https://orcid.org/0000-0001-7727-047X)
- Catherine Stratton (ORCID: https://orcid.org/0000-0002-1841-4565)
- Pallawi Torka (ORCID: https://orcid.org/0000-0002-1681-5883)
- Matthias Weiß (ORCID: https://orcid.org/0000-0001-8814-9915)
- Melissa Accordino (ORCID: https://orcid.org/0000-0002-4156-7279)
- Adam J. Olszewski (ORCID: https://orcid.org/0000-0002-6472-6658)
- Rana R. McKay (ORCID: https://orcid.org/0000-0002-0581-7963)
- Sanjay Mishra (ORCID: https://orcid.org/0000-0002-7775-9600)
- Trisha M. Wise‐Draper (ORCID: https://orcid.org/0000-0002-7279-4028)
- Christopher Su (ORCID: https://orcid.org/0000-0002-2700-2650)
- Daniel P. Mundt
- Yu Shyr (ORCID: https://orcid.org/0000-0003-2086-9670)
- Christopher R. Friese (ORCID: https://orcid.org/0000-0002-2281-2056)
- Babar Bashir (ORCID: https://orcid.org/0000-0002-6843-1179)
- Stephanie Berg (ORCID: https://orcid.org/0000-0001-6193-5350)
- Amanda Nizam (ORCID: https://orcid.org/0000-0001-5181-490X)
- Gary H. Lyman (ORCID: https://orcid.org/0000-0002-0823-8086)
- Hyma Vani Polimera (ORCID: https://orcid.org/0000-0001-5800-2111)
- Sarit Assouline (ORCID: https://orcid.org/0000-0002-7638-1589)
- Matthew Puc (ORCID: https://orcid.org/0000-0002-9281-2262)
- Daniel H. Kwon (ORCID: https://orcid.org/0000-0002-0830-7918)
- Xuanyi Li (ORCID: https://orcid.org/0000-0003-3943-4642)
- Rachel Rosovski
- Shailesh Advani (ORCID: https://orcid.org/0000-0002-1446-969X)
- Sumit Shah (ORCID: https://orcid.org/0000-0001-9479-2333)
- Daniel Hausrath (ORCID: https://orcid.org/0000-0002-9139-5938)
- Andrew Schmidt (ORCID: https://orcid.org/0000-0003-4930-4155)
- Keith Stockerl‐Goldstein (ORCID: https://orcid.org/0000-0002-7234-1715)
- Samuel M. Rubinstein (ORCID: https://orcid.org/0000-0003-3065-9220)
- Eric Lau (ORCID: https://orcid.org/0000-0002-8777-170X)
- Divaya Bhutani (ORCID: https://orcid.org/0000-0002-5482-7543)
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- UNC Libraries
- Published
- 2025-04-18
- DOI
- https://doi.org/10.17615/654a-sj66
- Primary Topic
- COVID-19 and healthcare impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00