Timing of adjuvant chemotherapy in patients with pancreatic ductal adenocarcinoma: A nationwide analysis
TTC in patients with upfront PDAC resection was not associated with survival, but TTC 6-12 weeks was associated with adjuvant chemotherapy completion. These findings support prioritizing postoperative recovery rather than pushing early adjuvant chemotherapy initiation.
Authors
- Daphne Roos (ORCID: https://orcid.org/0000-0003-0394-0842)
- Casper H.J. van Eijck (ORCID: https://orcid.org/0000-0002-9511-2157)
- G. Kazemier
- S. Festen
- Vincent P. Groot (ORCID: https://orcid.org/0000-0003-2102-3140)
- Marc G. Besselink (ORCID: https://orcid.org/0000-0003-2650-9350)
- Robert C. Verdonk (ORCID: https://orcid.org/0000-0001-5591-0499)
- Koop Bosscha (ORCID: https://orcid.org/0000-0002-7961-3314)
- Miriam L. Wumkes
- Martijn Intven (ORCID: https://orcid.org/0000-0002-5068-5517)
- Mike S.L. Liem (ORCID: https://orcid.org/0000-0001-8665-1506)
- Bas Groot Koerkamp (ORCID: https://orcid.org/0000-0003-1917-6973)
- Judith de Vos‐Geelen (ORCID: https://orcid.org/0000-0003-2578-1766)
- Geertjan van Tienhoven (ORCID: https://orcid.org/0000-0002-2516-2263)
- Olivier R. Busch (ORCID: https://orcid.org/0000-0001-9605-6831)
- Ronald M. van Dam (ORCID: https://orcid.org/0000-0001-8415-5090)
- Vincent Erwin de Meijer (ORCID: https://orcid.org/0000-0002-7900-5917)
- Bert A. Bonsing (ORCID: https://orcid.org/0000-0003-4513-5737)
- N C Biesma (ORCID: https://orcid.org/0009-0005-2891-0553)
- Martijn W.J. Stommel (ORCID: https://orcid.org/0000-0002-4257-5254)
- L. Urban (ORCID: https://orcid.org/0009-0002-0739-9512)
- Geert A. Cirkel (ORCID: https://orcid.org/0009-0007-8712-9825)
- Erwin van der Harst (ORCID: https://orcid.org/0000-0002-1317-5614)
- Lois A. Daamen (ORCID: https://orcid.org/0000-0001-9227-7178)
- Izaak Quintus Molenaar (ORCID: https://orcid.org/0000-0002-1585-7184)
- Ignace H. J. T. de Hingh (ORCID: https://orcid.org/0000-0003-3491-4268)
- H.C. van Santvoort
- P. Andel (ORCID: https://orcid.org/0009-0006-9341-9282)
- Iris W.J.M. van Goor (ORCID: https://orcid.org/0000-0003-3770-9841)
- Maartje Los (ORCID: https://orcid.org/0000-0002-4953-5271)
- Hanneke W. M. van Laarhoven (ORCID: https://orcid.org/0000-0003-3546-9709)
- Johanna W. Wilmink
- Vincent B. Nieuwenhuijs (ORCID: https://orcid.org/0000-0001-9311-8208)
- Jennifer M. J. Schreinemakers
- Fennie Wit (ORCID: https://orcid.org/0000-0002-1550-2607)
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- University of Groningen (NL)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Catharina Ziekenhuis (NL)
- Medisch Spectrum Twente (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Reinier de Graaf Hospital (NL)
- St. Antonius Ziekenhuis (NL)
- OLVG (NL)
- Amphia Ziekenhuis (NL)
- Maasstad Ziekenhuis (NL)
- Cancer Genomics Centre (NL)
- Isala (NL)
- Amsterdam University Medical Centers (NL)
- 's Heeren Loo (NL)
- Jeroen Bosch Ziekenhuis (NL)
- Maastro Clinic (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- European Journal of Surgical Oncology
- Published
- 2025-11-06
- DOI
- https://doi.org/10.1016/j.ejso.2025.111165
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00