Preclinical evaluation of epetraborole in the hollow fibre system model of <i>Mycobacterium abscessus</i> lung disease
Epetraborole microbial kill is the best, thus far, achieved in the HFS-MAB, more than two times omadacycline's 123 cfu/mL below B0. We propose to test a novel combination regimen of epetraborole plus omadacycline plus a β-lactam versus GBT first in the HFS-MAB, followed by clinical trials.
Authors
- Minh-Vu H Nguyen (ORCID: https://orcid.org/0000-0001-7598-7362)
- Shashikant Srivastava (ORCID: https://orcid.org/0000-0002-8786-8851)
- Tawanda Gumbo (ORCID: https://orcid.org/0000-0001-7592-8012)
- Charles L. Daley (ORCID: https://orcid.org/0000-0003-3324-926X)
- Gunavanthi D. Boorgula (ORCID: https://orcid.org/0000-0003-1749-3705)
- Sanjay Singh (ORCID: https://orcid.org/0000-0003-4601-5673)
Institutions
- Great Zimbabwe University (ZW)
- Texas A&M University System (US)
- The University of Texas at Tyler (US)
- National Jewish Health (US)
- 490 BioTech (United States) (US)
- University of California Davis Medical Center (US)
- University of Colorado Anschutz Medical Campus (US)
- University of California, Davis (US)
- The University of Texas Health Science Center at Tyler (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1093/jac/dkaf405
- Citations
- 1
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 1.35