Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus
P. melaninogenica enhanced neutrophil and epithelial defense against S. aureus, but the benefits of epithelial cell regulation by P. melaninogenica were lost with CFTR dysfunction. CFTR modulators rescued P. melaninogenica responsiveness in epithelial cells, highlighting the potential for synergistic effects of host-microbiome interactions and CFTR targeted therapies.
Authors
- Eric D. Larson (ORCID: https://orcid.org/0000-0002-2881-4861)
- Sarah Elizabeth Clark (ORCID: https://orcid.org/0000-0002-5975-5032)
- Sam Fulte (ORCID: https://orcid.org/0009-0008-8206-2948)
- Paul J. Planet (ORCID: https://orcid.org/0000-0003-0543-0539)
- Ana Fairbanks-Mahnke
- Arianna McCarty (ORCID: https://orcid.org/0009-0000-2062-8936)
- M. Goryachok (ORCID: https://orcid.org/0009-0001-8556-0722)
- Emily Tamkin (ORCID: https://orcid.org/0009-0008-7025-5486)
Institutions
- Children's Hospital of Philadelphia (US)
- Translational Therapeutics (United States) (US)
- University of Pennsylvania (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of Cystic Fibrosis
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.jcf.2025.11.002
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Jewish Health
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- University of Colorado School of Medicine, Anschutz Medical Campus