Targeted Oral Peptide Icotrokinra for Psoriasis Involving High-Impact Sites
At 16 weeks, significantly higher proportions of participants 12 years of age and over with at least moderate psoriasis involving high-impact sites treated with icotrokinra versus placebo achieved clearance or minimal psoriasis in their skin overall and in the scalp and genital areas, but not in their hands and feet. No safety signals were identified. (Funded by Johnson & Johnson; ClinicalTrials.gov number, NCT06095102.).
Authors
- Melinda Gooderham (ORCID: https://orcid.org/0000-0001-8926-0113)
- Jessica Rubens (ORCID: https://orcid.org/0000-0001-9198-9149)
- Charles W Lynde (ORCID: https://orcid.org/0000-0001-9163-5463)
- Takayuki Ota
- Oliver Weirich
- Robert Bissonnette (ORCID: https://orcid.org/0000-0001-5927-6587)
- Edward Lain (ORCID: https://orcid.org/0000-0002-3805-9441)
- Amy M. DeLozier (ORCID: https://orcid.org/0000-0001-8543-4534)
- Fabio P. Nunes (ORCID: https://orcid.org/0000-0002-8833-2223)
- Eingun James Song (ORCID: https://orcid.org/0000-0001-9735-0100)
- Yu‐Huei Huang (ORCID: https://orcid.org/0000-0003-0574-1839)
- Richard Bruce Warren (ORCID: https://orcid.org/0000-0002-2918-6481)
- Cynthia Marie Carver DeKlotz (ORCID: https://orcid.org/0000-0002-6410-8710)
- Shu Li (ORCID: https://orcid.org/0000-0003-3164-1348)
- Ming-Chun Hsu (ORCID: https://orcid.org/0000-0003-1527-3135)
- Matthias Hoffmann
- Raul Hernan Gabriel Ceitlin
Institutions
- Johnson & Johnson (United States) (US)
- Chang Gung University (TW)
- University of Toronto (CA)
- Manchester Academic Health Science Centre (GB)
- Chang Gung Memorial Hospital (TW)
- SKiN Health (CA)
- Lynde Centre for Dermatology (CA)
- Probity Medical Research (CA)
- Houston Institute for Clinical Research (US)
- Rosenpark Klinik (DE)
- Innovaderm (Canada) (CA)
- Autonomous Healthcare (US)
- NIHR Manchester Biomedical Research Centre (GB)
Publication Details
- Journal
- NEJM Evidence
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1056/evidoa2500155
- Citations
- 9
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 7.18