Multi-Institutional Assessment of Circulating Cell-Free DNA in Cerebrospinal Fluid Facilitates Central Nervous System Lymphoma Diagnosis and Treatment Initiation
These findings support the utilization of rapid PCR of cell-free DNA as a diagnostic method that may obviate tissue biopsy in the diagnosis of CNS lymphoma. Liquid biopsy to detect the MYD88 L265P variant is a rapid, feasible, and safe method for diagnosing CNS lymphoma.
Authors
- Bob S. Carter (ORCID: https://orcid.org/0000-0002-3586-1324)
- Daniel P. Cahill (ORCID: https://orcid.org/0000-0003-2552-6546)
- N. Zeke Georgantas
- Briana C. Prager (ORCID: https://orcid.org/0000-0001-7173-6021)
- Timothy R. West (ORCID: https://orcid.org/0000-0002-6444-6939)
- Jörg Dietrich (ORCID: https://orcid.org/0000-0001-8291-0136)
- Alireza Mansouri (ORCID: https://orcid.org/0000-0002-7442-7539)
- Justin T. Jordan (ORCID: https://orcid.org/0000-0001-6198-817X)
- Leonardo de Macêdo Filho (ORCID: https://orcid.org/0000-0002-8146-7889)
- Mihir Gupta (ORCID: https://orcid.org/0000-0003-1329-2906)
- Brian V. Nahed (ORCID: https://orcid.org/0000-0001-8537-106X)
- Deborah Anne Forst (ORCID: https://orcid.org/0000-0002-8428-0841)
- Charlotte I. Wang (ORCID: https://orcid.org/0009-0000-3512-8635)
- Ganesh M. Shankar
- Christopher Michael Ramundo
- Jack Bagin
- Rachel H. Pilacky
Institutions
- Yale New Haven Hospital (US)
- University of Utah (US)
- Massachusetts General Hospital (US)
- Center for Neuro-Oncology (US)
- Center for Cancer Research (US)
- Penn State Milton S. Hershey Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Neurosurgery
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1227/neu.0000000000003835
- Primary Topic
- CNS Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00