In Vivo Imaging of Blood-Brain Barrier Leakage Using a Contrast Agent in Patients With Cerebral Amyloid Angiopathy
Leakage of gadolinium-based contrast agent through the BBB can be measured in vivo in CAA from the leptomeningeal vessels, and findings point to likely leakage from cortical small vessels as well. Leakage from leptomeningeal vessels was associated with cSS. Studies with follow-up data need to determine whether these measures could serve as a predictive biomarker in CAA.
Authors
- Susanne J. van Veluw (ORCID: https://orcid.org/0000-0002-7957-8643)
- Sabine Voigt (ORCID: https://orcid.org/0000-0002-5182-6676)
- Michael J. Thrippleton (ORCID: https://orcid.org/0000-0001-7858-9917)
- Whitney M. Freeze (ORCID: https://orcid.org/0000-0001-9418-0214)
- Thijs W. van Harten (ORCID: https://orcid.org/0000-0002-3408-9379)
- Mariel G. Kozberg (ORCID: https://orcid.org/0000-0002-9358-3262)
- Anand Viswanathan (ORCID: https://orcid.org/0000-0001-5398-1816)
- Matthias J.P. van Osch (ORCID: https://orcid.org/0000-0001-7034-8959)
- Nazanin Makkinejad (ORCID: https://orcid.org/0000-0001-8153-743X)
- Hilde van den Brink (ORCID: https://orcid.org/0000-0003-3094-0274)
- John E. Kirsch (ORCID: https://orcid.org/0000-0002-0389-9475)
Institutions
- Leiden University Medical Center (NL)
- Massachusetts General Hospital (US)
- UK Dementia Research Institute (GB)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- University of Edinburgh (GB)
Publication Details
- Journal
- Neurology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1212/wnl.0000000000214336
- Citations
- 4
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- Universiteit Leiden
- Universiteit Maastricht
- Maastricht Universitair Medisch Centrum
- Leids Universitair Medisch Centrum
- National Institutes of Health
- Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital