Effects of Heavy Alcohol Use on Acute Intracerebral Hemorrhage and Cerebral Small Vessel Disease
HAU is associated with younger age at ICH onset, larger hematoma size, and imaging features consistent with more advanced hypertensive cSVD, including a greater burden of white matter hyperintensities. These findings suggest that HAU may exacerbate acute ICH severity and accelerate long-term cerebral small vessel pathology. Study limitations include the cross-sectional design, MRI availability restricted to a subset, and lack of detailed lifetime alcohol exposure. Future studies should clarify alcohol-related mechanisms underlying cSVD progression and ICH severity and inform prevention strategies.
Authors
- Christopher D. Anderson (ORCID: https://orcid.org/0000-0002-0053-2002)
- Jonathan Rosand (ORCID: https://orcid.org/0000-0002-1014-9138)
- Ofer Rotschild
- Elif Gökçal (ORCID: https://orcid.org/0000-0003-3309-4368)
- Andrea Morotti (ORCID: https://orcid.org/0000-0002-6558-1155)
- Joshua N. Goldstein (ORCID: https://orcid.org/0000-0002-6406-1828)
- Alvin S. Das (ORCID: https://orcid.org/0000-0003-2313-977X)
- M. Edip Gurol (ORCID: https://orcid.org/0000-0002-2169-4457)
- Zora DiPucchio
- Anand Viswanathan (ORCID: https://orcid.org/0000-0001-5398-1816)
- Steven Mark Greenberg (ORCID: https://orcid.org/0000-0003-1792-8887)
- Mette Foldager Hindsholm (ORCID: https://orcid.org/0009-0003-9482-2792)
- Claus Z. Simonsen (ORCID: https://orcid.org/0000-0003-1363-0266)
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Aarhus University Hospital (DK)
- Massachusetts General Hospital (US)
- University of Brescia (IT)
Publication Details
- Journal
- Neurology
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1212/wnl.0000000000214348
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00