To Convert or Not to Convert? Official International Association of Therapeutic Drug Monitoring and Clinical Toxicology Guideline: Considerations and Recommendations for Converting Capillary Blood Microsampling Concentrations to Plasma Concentrations
Key points include the importance of conducting a comprehensive clinical validation study to fully understand capillary blood microsampling results. In addition, the performance of the conversion method should be evaluated case by case, as it depends on both the microsampling-based method and analyte of interest. Furthermore, an independent set of paired capillary and venous samples should be used to validate an established conversion formula. Finally, a key point for future studies is to focus on the clinical impact of (converted) capillary blood concentrations in comparison with decisions based on results in the reference matrix to guarantee any microsampling-based outcome.
Authors
- Jan‐Willem C. Alffenaar (ORCID: https://orcid.org/0000-0001-6703-0288)
- Anders Åsberg (ORCID: https://orcid.org/0000-0002-0628-1769)
- Liesl Heughebaert (ORCID: https://orcid.org/0000-0002-6368-8215)
- Laura Boffel (ORCID: https://orcid.org/0000-0002-2626-9433)
- Theo Rispens (ORCID: https://orcid.org/0000-0001-9600-1312)
- Dirk Jan A. R. Moes (ORCID: https://orcid.org/0000-0003-3219-253X)
- Annick de Vries (ORCID: https://orcid.org/0000-0001-7570-473X)
- Brenda C. M. de Winter (ORCID: https://orcid.org/0000-0002-4452-8443)
- Maria Shipkova (ORCID: https://orcid.org/0000-0003-3790-6634)
- Christophe Pol Stove (ORCID: https://orcid.org/0000-0001-7126-348X)
- Hanna De Baets
Institutions
- Oslo University Hospital (NO)
- The University of Sydney (AU)
- University of Oslo (NO)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Westmead Hospital (AU)
- Sanquin (NL)
- Ghent University (BE)
- Netherlands Center for Occupational Diseases (NL)
- BioScientia (Poland) (PL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Therapeutic Drug Monitoring
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1097/ftd.0000000000001393
- Citations
- 4
- Primary Topic
- Biosimilars and Bioanalytical Methods
- Type
- article
- Field-Weighted Citation Impact
- 3.19