ALDH1 AND ALCAM AS EMERGING BIOMARKERS IN PERSONALIZED RECTAL CANCER THERAPY
Serum concentrations of ALCAM and ALDH1 were significantly elevated in our patient cohort with rectal cancer but showed no significant correlation with tumor stage or survival, whenever serum samples were obtained either during or after neoadjuvant and adjuvant therapy, which may be particularly due to the limited number of studied subjects. Although their prognostic utility remains limited, their consistent elevation in cancer patients underscores their potential value in early detection or as components of a broader biomarker panel.
Authors
- Carmen Austrália Paredes Marcondes Ribas (ORCID: https://orcid.org/0000-0002-6195-046X)
- Jurandir Marcondes Ribas-Filho (ORCID: https://orcid.org/0000-0002-5251-7672)
- Bülent Polat (ORCID: https://orcid.org/0000-0003-4677-424X)
- Ana Maria Waaga Gasser (ORCID: https://orcid.org/0000-0001-5437-716X)
- Reinhard Lissner (ORCID: https://orcid.org/0009-0000-6091-2640)
- Osvaldo Malafaia (ORCID: https://orcid.org/0000-0002-1829-7071)
- M Gasser (ORCID: https://orcid.org/0000-0002-0797-169X)
- Sudipta Tripathi (ORCID: https://orcid.org/0000-0001-7729-9002)
- Thomas Boeldicke (ORCID: https://orcid.org/0000-0003-2869-1133)
- Efstathia N Doelken (ORCID: https://orcid.org/0009-0001-1683-6780)
Institutions
- Brigham and Women's Hospital (US)
- University of Massachusetts Chan Medical School (US)
- University of Würzburg (DE)
- Evangelical Theological Faculty (BE)
- Augenklinik Universitätsklinikum Würzburg (DE)
- Helmholtz Centre for Infection Research (DE)
- Helmholtz Institute for RNA-based Infection Research (DE)
- Universitätsklinikum Würzburg (DE)
- Faculdade Evangélica do Paraná (BR)
Publication Details
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1590/0102-67202025000051e1920
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00