Beyond Alzheimer’s disease—translating biomarker insights across CNS diseases
Decades of research on biomarker identification and integration in Alzheimer's disease (AD) have helped to advance biologically driven disease models, disease subtypes, and disease-modifying treatments. Key lessons learned from AD biomarker development include the need for integration of new biological insights, investment in large cross-sectional and longitudinal studies, a multicomponent biomarker approach, and recruitment of clinical trial cohorts and biosamples that are representative of the target population. We describe how these lessons are being applied in Parkinson's disease, Huntington's disease, multiple sclerosis, and psychotic disorders as use cases to inform biomarker-based approaches across central nervous system disorders.
Authors
- Simin Mahinrad (ORCID: https://orcid.org/0000-0002-5927-7130)
- Alan Anticevic (ORCID: https://orcid.org/0000-0002-4324-0536)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Rebecca M. Edelmayer (ORCID: https://orcid.org/0000-0002-0169-9832)
- Samantha J. Hutten (ORCID: https://orcid.org/0000-0002-8435-744X)
- Charisse N. Winston (ORCID: https://orcid.org/0000-0002-1966-9252)
- Linda S. Brady (ORCID: https://orcid.org/0000-0001-7856-9086)
- Timothy Coetzee (ORCID: https://orcid.org/0000-0002-3031-7549)
- Carol Taylor‐Burds (ORCID: https://orcid.org/0000-0002-6784-2232)
- Jane S. Paulsen (ORCID: https://orcid.org/0000-0002-0983-228X)
- Valentina Mantua
- Sudhir Sivakumaran (ORCID: https://orcid.org/0000-0002-8586-0469)
- William J. Jagust (ORCID: https://orcid.org/0000-0002-4458-113X)
- William Z. Potter (ORCID: https://orcid.org/0000-0003-2529-6568)
- Hartmuth C. Kolb (ORCID: https://orcid.org/0000-0003-2414-5792)
- Eva P. Childers (ORCID: https://orcid.org/0000-0002-9127-8758)
- Leslie M. Shaw (ORCID: https://orcid.org/0000-0002-7650-1210)
- John A. Wagner (ORCID: https://orcid.org/0000-0002-0636-5006)
- Vikas Sharma (ORCID: https://orcid.org/0009-0009-1458-6085)
Institutions
- University of Southern California (US)
- Alzheimer's Association (US)
- United States Food and Drug Administration (US)
- Mayo Clinic (US)
- National Multiple Sclerosis Society (US)
- University of Wisconsin–Madison (US)
- National Academies of Sciences, Engineering, and Medicine (US)
- WinnMed (US)
- Michael J. Fox Foundation (US)
- Knoxville College (US)
- Yale University (US)
- National Institute of Neurological Disorders and Stroke (US)
- Nia Association (US)
- ISO Arzneimittel (Germany) (DE)
- Bioinstitut (CZ)
- National Institute of Mental Health (US)
- University of Pennsylvania (US)
- Southern States University (US)
- Philadelphia University (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Science Translational Medicine
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1126/scitranslmed.adr2511
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00