A multi-dimensional bioinformatic dissection of the molecular mechanisms in high-BMI–associated colorectal cancer: identification and validation of EGLN1 as a key target

This study systematically reveals the critical protective role of EGLN1 in high BMI-associated CRC and underscores its value as a potential drug target. EGLN1 influences CRC pathogenesis by modulating multiple dimensions, including the hypoxia response, energy metabolism, the immune microenvironment, and the gut microbiota. The natural compound cianidanol, as a modulator of EGLN1 , demonstrated significant anti-tumor activity in vitro . These findings provide new insights into the molecular mechanisms linking obesity and CRC and establish a theoretical foundation for developing precision therapeutic strategies targeting EGLN1 .