Relationship between HLA-DRB1 shared epitope alleles and peripheral blood monocyte counts in Japanese patients with rheumatoid arthritis

This is the first study to demonstrate a significant association between SE alleles and peripheral blood monocyte counts in RA. The results obtained suggest that specific SE alleles, particularly S3P alleles, contribute to the early pathogenesis of RA by enhancing monocyte-driven immune activation and anti-CCP Ab production.

Authors

Jun Ishizaki (ORCID: https://orcid.org/0000-0001-6287-5011)
Kenta Horie (ORCID: https://orcid.org/0000-0003-4175-1014)
D. Hiraoka (ORCID: https://orcid.org/0000-0003-3645-3872)
Katsuto Takenaka
Shin-ichi Mizuki
Kensuke Oryoji

Institutions

Matsuyama Red Cross Hospital (JP)
Ono Clinic (JP)
Ehime University (JP)

Publication Details

Journal: PLoS ONE
Published: 2025-11-05
DOI: https://doi.org/10.1371/journal.pone.0336214
Primary Topic: Rheumatoid Arthritis Research and Therapies
Type: article
Field-Weighted Citation Impact: 0.00

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article

Relationship between HLA-DRB1 shared epitope alleles and peripheral blood monocyte counts in Japanese patients with rheumatoid arthritis

Jun Ishizaki, Kenta Horie, D. Hiraoka, Katsuto Takenaka et al.

Nov 5, 2025

PLoS ONE

Rheumatoid Arthritis Research and Therapies

article

Relationship between HLA-DRB1 shared epitope alleles and peripheral blood monocyte counts in Japanese patients with rheumatoid arthritis

Jun Ishizaki, Kenta Horie, D. Hiraoka, Katsuto Takenaka, Shin-ichi Mizuki, Kensuke Oryoji

November 5, 2025article en

Abstract

This is the first study to demonstrate a significant association between SE alleles and peripheral blood monocyte counts in RA. The results obtained suggest that specific SE alleles, particularly S3P alleles, contribute to the early pathogenesis of RA by enhancing monocyte-driven immune activation and anti-CCP Ab production.

PLoS ONEVol. 20(11)

Matsuyama Red Cross Hospital (JP), Ono Clinic (JP), Ehime University (JP)

Openalex Percentile: Top 53%

Rheumatoid Arthritis Research and Therapies

DOI Open Access PDF OpenAlex

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Relationship between HLA-DRB1 shared epitope alleles and peripheral blood monocyte counts in Japanese patients with rheumatoid arthritis — Jun Ishizaki, Kenta Horie, et al. · PLoS ONE (2025) | TGRS Research Map | TGRS