New aromatic butenolides from the plant endophytic fungus <i>Malbranchea umbrina</i> D16
Five aromatic butenolides including two new ones, malbranketons A and B (<b>1</b> and <b>2</b>), were obtained from the <i>Euphorbia wallichii</i>-derived endophytic fungus <i>Malbranchea umbrina</i> D16. Their structures including the absolute configuration were elucidated by NMR, HRMS, ECD, and X-Ray data. All compounds were examined for their cytotoxic activities against four tumour cell lines H1975, Panc-1, A549, and 22RV-1, but without effects (IC<sub>50</sub> > 20 <i>μ</i>M).
Authors
- Gui‐Hua Tang (ORCID: https://orcid.org/0000-0002-8831-7154)
- Xian-An Chen
- Sheng Yin (ORCID: https://orcid.org/0000-0002-5678-6634)
- Leiming Wu (ORCID: https://orcid.org/0000-0002-2549-6458)
- Rong Pu (ORCID: https://orcid.org/0000-0002-2358-6150)
- Han‐Zhuang Weng
- Tao Yuan (ORCID: https://orcid.org/0000-0001-7746-3714)
- Shuqi Wu (ORCID: https://orcid.org/0000-0001-6483-4782)
Institutions
- Sun Yat-sen University (CN)
- Nanchang Normal University (CN)
- Dongguan People’s Hospital (CN)
- Jiangxi Normal University (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1080/14786419.2025.2581220
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00