BCOR Mutations Deregulate Cell Cycle and Hypoxic Adaptation Pathways in Retinoblastoma
This study reveals that BCOR may play a noncanonical, multifaceted role in retinoblastoma with implications in cell cycle, differentiation, and hypoxic adaptation, ultimately shedding insight into its molecular framework for future therapeutic strategies.
Authors
- Michelle G. Zhang (ORCID: https://orcid.org/0000-0002-4083-9009)
- Jeffim N. Kuznetsoff (ORCID: https://orcid.org/0000-0002-6197-2642)
- Daniel Pelaez (ORCID: https://orcid.org/0000-0002-4483-5160)
- Stefan Kurtenbach (ORCID: https://orcid.org/0000-0002-7445-596X)
- Zélia M. Corrêa (ORCID: https://orcid.org/0000-0003-2946-3757)
- Susana Salazar (ORCID: https://orcid.org/0009-0007-6884-9536)
- J. William Harbour (ORCID: https://orcid.org/0000-0002-1104-9809)
- Natalie C. Cetta (ORCID: https://orcid.org/0009-0002-3839-3455)
- Renata L. Volonterio (ORCID: https://orcid.org/0009-0004-0773-9622)
Institutions
- University of Miami (US)
- University of California, San Francisco (US)
- Southwestern Medical Center (US)
- Stem Cell Institute (PA)
- Sylvester Comprehensive Cancer Center (US)
- Southwestern Medical Center (US)
- University of San Francisco (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Molecular Cancer Research
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1158/1541-7786.mcr-24-1078
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00