Generalization of High-Throughput Experimentation in Organic Chemistry: Case Study on the Flortaucipir Synthesis
High-Throughput Experimentation has undergone an outstanding evolution in the past two decades and has proven to be a game-changer in the acceleration of reaction discovery and optimization. Despite a good implementation in the pharmaceutical industry and a demonstrated accessibility to the technology, the generalization of High-Throughput Experimentation as a standard method for optimizing reactions is not yet observed. The perspective aims at discussing the necessity of generalizing such technologies, supported by the case study: the optimization by High-Throughput Experimentation of a key step in the synthesis of Flortaucipir, an FDA-approved imaging agent for Alzheimer’s diagnosis.
Authors
- Milene M. Hornink (ORCID: https://orcid.org/0000-0002-6832-7259)
- David‐Alexandre Buisson
- Jean‐Christophe Cintrat (ORCID: https://orcid.org/0000-0001-5758-8077)
- Sabrina Lebrequier
- Eugénie Romero (ORCID: https://orcid.org/0000-0003-0484-1221)
- Gaëtan Ossard
Institutions
- Centre National de la Recherche Scientifique (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- CEA Paris-Saclay - Etablissement de Fontenay-aux-roses (FR)
- Technologies pour la Santé (FR)
- Direction de la Recherche Fondamentale (FR)
- CEA Paris-Saclay (FR)
- Universidade São Francisco (BR)
Publication Details
- Journal
- Organics
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3390/org6040050
- Primary Topic
- Innovative Microfluidic and Catalytic Techniques Innovation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo