Helicobacter pylori antimicrobial resistance and CYP2C19 genotypes in a paediatric cohort with initial eradication failure: A study from Henan, China (2019–2024)
The high resistance rates to MTZ and CLA, coupled with the CYP2C19 EM phenotype, may contribute to the failure of initial empirical H. pylori eradication in children from Henan, China. Therefore, for retreatment, it is recommended to tailor an individualized regimen based on antimicrobial susceptibility testing and CYP2C19 genotyping results.
Authors
- Fang Liz Zhou (ORCID: https://orcid.org/0000-0003-1353-6376)
- Fumin Xue (ORCID: https://orcid.org/0000-0002-8097-0108)
- J. Hou (ORCID: https://orcid.org/0000-0001-9159-8746)
- Cong Ding (ORCID: https://orcid.org/0000-0002-6808-9975)
- Bo Sun (ORCID: https://orcid.org/0000-0002-5548-3850)
- Chao An (ORCID: https://orcid.org/0000-0002-3254-6871)
- Jing Yu (ORCID: https://orcid.org/0000-0002-8584-4952)
- Qiang Zhou (ORCID: https://orcid.org/0000-0001-5827-0044)
Institutions
- Zhengzhou University (CN)
- Zhengzhou Children's Hospital (CN)
- Second Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.jgar.2025.10.024
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00