Mechanistic investigation of quercetin (an active component of RAS-RH) in modulating radiation-induced coronary microvascular dysfunction via the TCs-ECs crosstalk pathway
These results collectively demonstrate that quercetin, the primary active component of RAS-RH, suppresses excessive mPTP activation and apoptosis while stimulating ECs migration and tube formation. This occurs via upregulating HIF-1α and miRNA-126 expression in TCs and enhancing miRNA-126 paracrine to ECs, positioning the TCs-ECs crosstalk mechanism as a promising novel therapeutic target for intervening in coronary microcirculation dysfunction.
Authors
- Chunzhen Ren (ORCID: https://orcid.org/0000-0003-1422-0488)
- Liu Ai (ORCID: https://orcid.org/0000-0001-8222-2157)
- Xinke Zhao (ORCID: https://orcid.org/0000-0001-9626-7313)
- Jiang Hugang
- Kai Liu (ORCID: https://orcid.org/0000-0003-0878-5191)
- Yingdong Li (ORCID: https://orcid.org/0000-0001-7184-7290)
- Guo Zeao
- Lin Wenyan
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
- Gansu Provincial Hospital (CN)
- Pingliang People's Hospital (CN)
Publication Details
- Journal
- Microvascular Research
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1016/j.mvr.2025.104883
- Citations
- 1
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 1.39