KLF9 drives intermittent hypoxia-induced MASLD by suppressing the NR4A1–p38 MAPK hepatic metabolic axis
This study identifies KLF9 as a key transcriptional regulator driving IH-associated MASLD by repressing NR4A1 and inhibiting p38 MAPK signaling, thereby promoting hepatic lipogenesis. Targeting the KLF9-NR4A1 axis may offer a novel therapeutic approach for managing MASLD in patients with OSA and other hypoxia-related disorders.
Authors
- Jingya Gao (ORCID: https://orcid.org/0000-0001-6477-8928)
- Gong‐Hong Wei (ORCID: https://orcid.org/0000-0001-6546-9334)
- Hongting Hua (ORCID: https://orcid.org/0000-0003-3972-050X)
- Dongyu Si
- Chaobing Gao
- Hongli Wang (ORCID: https://orcid.org/0000-0002-6153-0983)
- Miao Zhang (ORCID: https://orcid.org/0000-0001-9899-0767)
- Wei Xiang (ORCID: https://orcid.org/0000-0002-0608-065X)
- Dong Wang (ORCID: https://orcid.org/0000-0003-0489-0859)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-5350-741X)
- Yang Xiao (ORCID: https://orcid.org/0000-0001-7144-9276)
- Nuo Chen (ORCID: https://orcid.org/0000-0002-5340-1399)
- Zongshi Gao
- W. Jiang (ORCID: https://orcid.org/0000-0003-4729-8302)
- Ling He (ORCID: https://orcid.org/0000-0002-2513-6233)
- Huabing Zhang (ORCID: https://orcid.org/0000-0001-8402-7830)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Anhui Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University Shanghai Cancer Center (CN)
- Nanfang Hospital (CN)
- Suzhou Institute of Systems Medicine (CN)
- Fuyang Maternity and Child Health Care Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1097/hep.0000000000001606
- Citations
- 3
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 2.42