Epigenetic repression of hepatocyte FoxO1 disrupts local immune homeostasis and promotes liver inflammation
Our findings uncover a hitherto unrecognized mechanism for hepatocyte-based control of liver inflammation, in which hepatocyte FoxO1 maintained by JMJD1C restrains local NKT cells and neutrophils via CD1d induction, providing promising targets for inflammatory liver diseases.
Authors
- Xiaojun Chen (ORCID: https://orcid.org/0000-0002-3698-2814)
- Z Wang (ORCID: https://orcid.org/0009-0007-8695-8576)
- Weijie Xue
- Zhigang Lei (ORCID: https://orcid.org/0000-0003-1156-1973)
- Chunyan Ye
- Shouguo Liu (ORCID: https://orcid.org/0009-0005-8308-7299)
- Chuan Su (ORCID: https://orcid.org/0000-0002-8271-2428)
- Yuxin Zhang (ORCID: https://orcid.org/0009-0004-0736-0815)
- Xiujun Zhang (ORCID: https://orcid.org/0000-0001-8041-0592)
- Yalin Li (ORCID: https://orcid.org/0000-0002-2585-8172)
- Jifeng Zhu
- Sha Zhou (ORCID: https://orcid.org/0000-0002-7468-1924)
- Dongmei Zhu (ORCID: https://orcid.org/0000-0002-2557-1243)
- Wu Yu (ORCID: https://orcid.org/0000-0002-4031-144X)
- Lei Xu (ORCID: https://orcid.org/0009-0001-5297-7046)
- Chenxu Mao
- C. M. Huang (ORCID: https://orcid.org/0000-0002-6528-3334)
- Junyao Shen
Institutions
- Jiangsu Provincial Center for Disease Control and Prevention (CN)
- Changzhou No.2 People's Hospital (CN)
- Jiangsu Province Hospital (CN)
- Changzhou Third People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2025-11-04
- DOI
- https://doi.org/10.1097/hep.0000000000001590
- Citations
- 1
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.32