Hearing Loss, Brain Structure, Cognition, and Dementia Risk in the Framingham Heart Study
This cohort study found that midlife hearing loss was associated with smaller brain volumes, accelerated worsening in executive function, and an increased risk of dementia, suggesting that it may be an early marker of brain aging and dementia risk.
Authors
- Evan Fletcher (ORCID: https://orcid.org/0000-0002-9761-3131)
- Lily Francis
- Jared M. Zucker
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Debora Melo van Lent (ORCID: https://orcid.org/0000-0002-7392-9289)
- Christopher G. Wood
- D. Bradley Welling (ORCID: https://orcid.org/0000-0002-9963-469X)
- Timothy L. Kowalczyk
- Sharon G. Kujawa
- Pauline Maillard (ORCID: https://orcid.org/0000-0003-3516-6345)
- Sophia Francesca DP Lu (ORCID: https://orcid.org/0000-0002-2002-9818)
- Nancy L. Heard‐Costa (ORCID: https://orcid.org/0000-0001-9730-0306)
- Alexa S. Beiser (ORCID: https://orcid.org/0000-0001-8551-7778)
- Charles DeCarli (ORCID: https://orcid.org/0000-0003-1914-2693)
- Francis Babaman Kolo (ORCID: https://orcid.org/0000-0003-2872-8864)
- Monica Gireud (ORCID: https://orcid.org/0000-0001-5172-2351)
- Shu Jie Ting (ORCID: https://orcid.org/0009-0002-5577-7696)
- Saptaparni Ghosh (ORCID: https://orcid.org/0009-0009-6280-1624)
- Alexander Banerjee (ORCID: https://orcid.org/0000-0003-1649-6939)
- Jayandra J. Himali
Institutions
- Boston University (US)
- Massachusetts Eye and Ear Infirmary (US)
- The University of Texas at San Antonio Health Science Center (US)
- Sarah Cannon Research Institute (GB)
- Sarah Cannon (US)
- Institute for Neurodegenerative Disorders (US)
- University of California, Davis (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.39209
- Citations
- 2
- Primary Topic
- Hearing Loss and Rehabilitation
- Type
- article
- Field-Weighted Citation Impact
- 2.86