Ketogenic Diets and Depression and Anxiety
In this systematic review and meta-analysis, KDs were associated with modest improvements in depressive symptoms, particularly with biochemical ketosis verification, while anxiety evidence was inconclusive. Given heterogeneity, comparators, and short follow-up, well-powered trials with standardized, verified protocols, structured support, and prespecified outcomes are needed to confirm efficacy and durability.
Authors
- Reinhard Janssen‐Aguilar (ORCID: https://orcid.org/0000-0001-5340-9078)
- Wendy Lou (ORCID: https://orcid.org/0000-0001-5590-8719)
- Shakila Meshkat (ORCID: https://orcid.org/0000-0002-7010-1785)
- Hugo Laviada‐Molina (ORCID: https://orcid.org/0000-0002-1061-3164)
- Huda Al-Shamali (ORCID: https://orcid.org/0000-0002-3995-7075)
- Mary L. Phillips (ORCID: https://orcid.org/0009-0007-2868-1169)
- Malika Peera
- Qiaowei Lin
- Tulassi Vije
Institutions
- St. Michael's Hospital (CA)
- University of Pittsburgh (US)
- University of Toronto (CA)
- Public Health Ontario (CA)
- Universidad Marista de Mérida (MX)
Publication Details
- Journal
- JAMA Psychiatry
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1001/jamapsychiatry.2025.3261
- Citations
- 3
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 3.49