Human coronavirus OC43 infection in human cerebral organoids: novel insights on pathogenesis and potential therapeutic interventions
Conclusively, HCOs infected with HCoV-OC43 offer valuable insights into the pathogenesis of HCoVs in central nervous system (CNS), and might serve as a tool for developing novel therapeutic strategies for HCoVs infections, including COVID-19, especially on exploring treatment candidates.
Authors
- Wenjie Tan (ORCID: https://orcid.org/0000-0002-5963-1136)
- Changcheng Wu (ORCID: https://orcid.org/0000-0002-2428-8630)
- Jingdong Song (ORCID: https://orcid.org/0000-0001-8808-1981)
- Wen‐Ching Wang (ORCID: https://orcid.org/0000-0002-7422-3667)
- Chengcheng Zhai
- Baoying Huang (ORCID: https://orcid.org/0000-0001-9516-1146)
- Weibang Huo (ORCID: https://orcid.org/0009-0004-2210-8239)
- Lan Wei (ORCID: https://orcid.org/0000-0002-4302-0613)
- Gaoqian Zhang
- Na Zhu
- Roujian Lu (ORCID: https://orcid.org/0000-0002-3362-662X)
- Yao Deng
- Juntong Liu (ORCID: https://orcid.org/0000-0003-1465-4171)
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- National Institute for Viral Disease Control and Prevention (CN)
- National Institute for Communicable Disease Control and Prevention (CN)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s12929-025-01193-z
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universiteit van Amsterdam
- National Key Research and Development Program of China