Revisiting p53 Immunohistochemical Staining and Its Prognostic Implications in Advanced EGFR-Mutated Lung Adenocarcinoma
Tumor p53 immunostaining (≥50%) was associated with better OS, especially in patients with <i>TP53</i> mutations or L858R. Prospective clinical trials are required to explore the prognostic significance of p53 expression in the genomic era of <i>TP53</i> mutations.
Authors
- Kam-Fai Lee
- Meng‐Hung Lin (ORCID: https://orcid.org/0000-0002-8594-3360)
- Yao-Ren Yang
- Chen-Lin Chi
- Shun‐Fu Chang (ORCID: https://orcid.org/0000-0002-2276-7785)
- Chung‐Sheng Shi (ORCID: https://orcid.org/0000-0002-5548-7675)
- Feng‐Che Kuan (ORCID: https://orcid.org/0000-0003-0501-5888)
- Fenfen Chen (ORCID: https://orcid.org/0009-0003-5355-1375)
- Yu-Ying Wu (ORCID: https://orcid.org/0000-0003-3858-4112)
Institutions
- Chang Gung University of Science and Technology (TW)
- Chang Gung University (TW)
- Far Eastern Memorial Hospital (TW)
- Chiayi Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Cancers
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3390/cancers17213577
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Technology Agency of the Czech Republic