Shape Variations in Right Ventricular 3D Geometry Are Associated With Adverse Outcomes in Hypoplastic Left Heart Syndrome Patients: A Fontan Outcomes Registry Using CMR Examinations (FORCE) Study
Our statistical shape modeling analyses provide novel insights into RV geometric remodeling in HLHS and identify specific shape phenotypes associated with dysfunction and adverse outcomes. Shape-based metrics offer additive prognostic value beyond conventional volumetric analysis, with potential implications for risk stratification and surgical decision-making in single-ventricle physiology.
Authors
- Michael A. Quail (ORCID: https://orcid.org/0000-0002-7005-4720)
- M. Files
- Pierangelo Renella (ORCID: https://orcid.org/0000-0002-6444-2604)
- Alix Dorfman
- Aswathy Vaikom House (ORCID: https://orcid.org/0000-0001-8307-0597)
- Sarah Kollar (ORCID: https://orcid.org/0000-0002-3036-7407)
- Tarek Alsaied (ORCID: https://orcid.org/0000-0002-3777-4822)
- Ryan O’Hara (ORCID: https://orcid.org/0000-0002-7636-1799)
- Justin Weigand (ORCID: https://orcid.org/0000-0002-0016-8140)
- T Johnson
- J. O. ROBINSON
- Markus S. Renno (ORCID: https://orcid.org/0000-0001-8647-4386)
- Ria Garg (ORCID: https://orcid.org/0000-0002-4744-7024)
- Ravi Vegulla (ORCID: https://orcid.org/0000-0003-3645-5325)
- Amish H. Doshi (ORCID: https://orcid.org/0000-0002-2507-436X)
- Francesca Raimondi (ORCID: https://orcid.org/0000-0003-2580-151X)
- Rajesh Krishnamurthy (ORCID: https://orcid.org/0000-0002-9137-642X)
- Yue‐Hin Loke (ORCID: https://orcid.org/0000-0003-1003-1903)
- Jonathan H. Soslow (ORCID: https://orcid.org/0000-0001-9194-5330)
- Prasanna Ramachandran (ORCID: https://orcid.org/0000-0003-2568-7673)
- Kurt G. Stern
- Nicole Toscana Stanford (ORCID: https://orcid.org/0000-0002-2578-9795)
- Rittal Mehta (ORCID: https://orcid.org/0000-0002-0807-4763)
- Elias Balaras (ORCID: https://orcid.org/0000-0003-0132-4835)
- Tim Slesnick
- Francesco Capuano (ORCID: https://orcid.org/0000-0003-0274-5260)
- Vivek Muthurangu (ORCID: https://orcid.org/0000-0002-4292-6456)
- Susana Gaviria
- Sharath S. Hegde (ORCID: https://orcid.org/0000-0002-8975-2756)
- Jacqueline Contento (ORCID: https://orcid.org/0000-0002-5897-6132)
- Laura Olivieri
- Alix Fetch
- Uyen Truong (ORCID: https://orcid.org/0000-0002-5546-9266)
- Rahul H. Rathod (ORCID: https://orcid.org/0000-0002-7149-5421)
- Yves d’Udekem (ORCID: https://orcid.org/0000-0003-1851-7836)
- Alison L. Marsden (ORCID: https://orcid.org/0000-0003-1902-171X)
- Bijoy Thattaliyath (ORCID: https://orcid.org/0000-0001-5899-7729)
- J G Steele
- CZ Lam
- Amee Shah
- MA Fogel
- Meenakshi Aggarwal
Institutions
- Rutgers, The State University of New Jersey (US)
- Boston Children's Hospital (US)
- Children's National (US)
- George Washington University (US)
- Children's Hospital of Pittsburgh (US)
- Boston Children's Museum (US)
- Universitat Politècnica de Catalunya (ES)
Publication Details
- Journal
- Circulation Cardiovascular Imaging
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1161/circimaging.125.018455
- Citations
- 3
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 4.16