Ni(0)-Catalyzed Regiocontrolled Sila-Alkenylation of Aldehydes: A Heteroatom Inclusive Strategy
We report a Ni<sup>0</sup>-catalyzed regiocontrolled sila-alkenylation of <i>O</i>-allyl salicylaldehydes, enabling the synthesis of a diverse array of chromanols with exclusive <i>syn</i> selectivity. The methodology can also be applied to the construction of N-heterocycles and carbocycles. The Et<sub>3</sub>B/Et<sub>3</sub>SiH combination circumvents the key challenges to provide selective β-hydride elimination. The reaction order dependence was determined for each component of the reaction.
Authors
- Aankhi Khamrai
- Sudipta Ghosh (ORCID: https://orcid.org/0000-0002-6505-7994)
- Venkataraman Ganesh (ORCID: https://orcid.org/0000-0001-7893-109X)
Institutions
- Indian Institute of Technology Kharagpur (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1021/acs.orglett.5c03947
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94