Population-level allelic dispersion modeling by <i>maelstRom</i> yields genome-wide maps of allele-specific dysregulation during early carcinogenesis
Differential AD clearly indicates early dysregulation in renal cancer, complementing basic differential expression analysis in cancer transcriptomics. AD is also relevant to study random monoallelic expression and may equally detect allele-specific (dys)regulation during early development or in noncancer diseases. maelstRom is available as an open-source software package at github.com/Biobix/maelstRom.
Authors
- Tine Goovaerts
- Wim Van Criekinge (ORCID: https://orcid.org/0000-0003-2971-5539)
- S. Raine Cedric (ORCID: https://orcid.org/0000-0002-1952-0810)
- Louis Coussement (ORCID: https://orcid.org/0000-0003-1736-4962)
- Tim De Meyer (ORCID: https://orcid.org/0000-0003-2994-9693)
- Jeroen Galle (ORCID: https://orcid.org/0009-0003-4766-682X)
- Femke De Graeve (ORCID: https://orcid.org/0000-0001-6492-8308)
Institutions
- HOGENT University of Applied Sciences and Arts (BE)
- Ghent University (BE)
- Cancer Research Institute Ghent (BE)
Publication Details
- Journal
- GigaScience
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/gigascience/giaf125
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering