Transplacental Transfer of Lumefantrine, Mefloquine, and Piperaquine: A Comparison of Concentrations in Mothers, Neonates, and Cord Blood
Antimalarial drugs crossed the placenta variably. Neonatal concentrations ranged from less than half (lumefantrine, mefloquine) to near maternal equivalence (piperaquine). Collection of neonatal capillary samples at birth should be considered in future studies.SummaryWe compared antimalarial blood concentrations in mothers, neonates, and cords. Neonatal drug concentrations ranged from near maternal equivalence (piperaquine) to less than half (lumefantrine, mefloquine). Cord concentrations may underestimate neonatal exposure. Future studies should consider neonatal capillary sampling.
Authors
- Mary Ellen Gilder (ORCID: https://orcid.org/0000-0001-8811-8123)
- Hsa Eh
- Verena I. Carrara (ORCID: https://orcid.org/0000-0002-2758-0872)
- Ma Ner
- Urairat Koesukwiwat
- Aye Kyi Win
- Nicholas John White (ORCID: https://orcid.org/0000-0002-1897-1978)
- Joel Tärning (ORCID: https://orcid.org/0000-0003-4566-4030)
- Laypaw Archusuksan
- Makoto Saito (ORCID: https://orcid.org/0000-0002-1667-9287)
- Rose McGready (ORCID: https://orcid.org/0000-0003-1621-3257)
- François Nosten
- Naw Eh
- Laaongsri Niwetphongprai
Institutions
- University of Geneva (CH)
- Mahidol University (TH)
- Angkor Hospital for Children (KH)
- University of Oxford (GB)
- Shoklo Malaria Research Unit (TH)
- Institute for Advanced Medical Research (US)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
- Advanced Medical Research Institute (US)
- Geneva College (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1093/cid/ciaf552
- Citations
- 3
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 6.17