Synthesis and in vitro characterization of [198Au]Auranofin
[<sup>198</sup>Au]Auranofin (c.a.) represents a stable and effective radiogold-based radiopharmaceutical agent, offering redox-targeted cytotoxicity alongside β⁻ emission mediated cell death and γ emission based imaging potential. These findings highlight c.a. [<sup>198</sup>Au]Auranofin as a promising radiogold-based theranostic candidate, offering dual capabilities in targeted cytotoxicity and nuclear imaging. While the in vitro results are encouraging, further in vivo and translational studies are warranted to fully evaluate its clinical potential in nuclear medicine guided cancer therapy.
Authors
- Guilhem Claude (ORCID: https://orcid.org/0009-0000-0404-7242)
- Sarah Spreckelmeyer (ORCID: https://orcid.org/0000-0003-1348-0309)
- C. Gorges (ORCID: https://orcid.org/0000-0002-2372-7590)
- Winfried Brenner (ORCID: https://orcid.org/0000-0003-2478-6004)
- Christopher Geppert
- Punita Bhardwaj
- Caroline Frohner
Institutions
- Johannes Gutenberg University Mainz (DE)
- Humboldt-Universität zu Berlin (DE)
- German Cancer Society (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s41181-025-00401-3
- Citations
- 1
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36