Method-dependent release kinetics of the sustained-release bolus tablets: a comparative study using daisy II incubator and continuous artificial saliva systems
The binder type and concentration strongly influence dissolution kinetics, while the testing environment determines release predictability. Gum acacia at 2% concentration achieved the most controlled and stable release, and the Daisy II incubator most accurately simulated rumen conditions for predictive <i>in vitro</i> evaluation.
Authors
- Gürbüz Çomak (ORCID: https://orcid.org/0000-0002-7326-6710)
- Elizaveta Trofimushkına
Institutions
- Mersin Üniversitesi (TR)
Publication Details
- Journal
- Drug Development and Industrial Pharmacy
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1080/03639045.2025.2585139
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00