Yb(OTf) <sub>3</sub> -promoted synthesis of 3-fluoroquinoline <i>via</i> a decarboxylative Mannich-type reaction

We report a concise and practical one-pot synthesis of 3-fluoroquinolines via a decarboxylative Mannich-type reaction of α,α-difluoro-β-ketoesters with N -aryl imines in the presence of Yb(OTf) 3 .

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Publication Details

Journal
New Journal of Chemistry
Published
2025-01-01
DOI
https://doi.org/10.1039/d5nj03605d
Primary Topic
Fluorine in Organic Chemistry
Type
article
Field-Weighted Citation Impact
0.00
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article

Yb(OTf) 3 -promoted synthesis of 3-fluoroquinoline via a decarboxylative Mannich-type reaction

Atsushi Tarui, Yohei Yasuno, Kentaro Kawai, Masaaki Omote et al.
New Journal of Chemistry
Fluorine in Organic Chemistry
article

Yb(OTf) 3 -promoted synthesis of 3-fluoroquinoline via a decarboxylative Mannich-type reaction

Atsushi Tarui, Yohei Yasuno, Kentaro Kawai, Masaaki Omote, Shoki Hoshikawa, Kazuyuki Sato, Yukiko Karuo
article en

Abstract

We report a concise and practical one-pot synthesis of 3-fluoroquinolines via a decarboxylative Mannich-type reaction of α,α-difluoro-β-ketoesters with N -aryl imines in the presence of Yb(OTf) 3 .

New Journal of ChemistryVol. 49(45)
Setsunan University (JP)
Openalex Percentile: Top 74%
Fluorine in Organic Chemistry
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