Long‐Term Memory Updating Parallels Altered Awake and Sleep Hippocampal Replays

The activity of hippocampal place cells is essential for various processes of spatial memory, including encoding, consolidation, and retrieval. However, whether they also participate in spatial memory updating remains elusive. This study demonstrates that during the process of long-term spatial associative memory updating, triggered by changes in reward magnitudes in a maze over consecutive days, there is a distinct period characterized by loss of preference for different reward magnitudes before adapting to new magnitude ratios. During this period, sequential replays in the hippocampus during post-training sleep are significantly biased toward the region associated with the larger reward. Additionally, replays between trials show elevated predictive power for the upcoming choices. Our results suggest that hippocampal replays may play a key role in updating long-term spatial associative memory.

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Publication Details

Journal
Advanced Science
Published
2025-11-05
DOI
https://doi.org/10.1002/advs.202416480
Primary Topic
Memory and Neural Mechanisms
Type
article
Field-Weighted Citation Impact
0.00

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article

Long‐Term Memory Updating Parallels Altered Awake and Sleep Hippocampal Replays

Jibin Wu, Kun Cui, Longyu Ma, Jifu Tong et al.
Advanced Science
Memory and Neural Mechanisms
article

Long‐Term Memory Updating Parallels Altered Awake and Sleep Hippocampal Replays

Jibin Wu, Kun Cui, Longyu Ma, Jifu Tong, You Wan, Naizheng Liu, Shuting Liu, Shuang Cui, Xuetao Qi, Ting Wang, Yawen Zheng, Ming Yi, Shan Shao, Linshu Wang, Yuanwei Xing
article en

Abstract

The activity of hippocampal place cells is essential for various processes of spatial memory, including encoding, consolidation, and retrieval. However, whether they also participate in spatial memory updating remains elusive. This study demonstrates that during the process of long-term spatial associative memory updating, triggered by changes in reward magnitudes in a maze over consecutive days, there is a distinct period characterized by loss of preference for different reward magnitudes before adapting to new magnitude ratios. During this period, sequential replays in the hippocampus during post-training sleep are significantly biased toward the region associated with the larger reward. Additionally, replays between trials show elevated predictive power for the upcoming choices. Our results suggest that hippocampal replays may play a key role in updating long-term spatial associative memory.

Advanced ScienceVol. 13(3)
Peking University (CN), National Health and Family Planning Commission (CN), Beijing Academy of Science and Technology (CN), Taizhou University (CN)
National Natural Science Foundation of China, Peking University, National Key Research and Development Program of China
Openalex Percentile: Top 67%
Memory and Neural Mechanisms
DOIOpen Access PDFOpenAlex
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