Electrochemical N–H Phosphorodithiolation of Sulfoximines with P <sub>4</sub> S <sub>10</sub> and Alcohols
Coupling dithiophosphates with sulfoximines is a promising strategy for generating diverse bioactive products, but a mild and efficient method is highly desirable. Herein, an electrochemical method has been developed to achieve N-H phosphorodithiolation of sulfoximines, providing <i>N</i>-(diethylphosphorodithioate) sulfoximines with moderate to good yields in the absence of external chemical oxidants. Furthermore, this approach can be extended to the synthesis of (dialkylphosphorodithioate) sulfoximines by employing <i>in situ</i> generated dialkylphosphorodithioate from P<sub>4</sub>S<sub>10</sub> and alcohols in one pot.
Authors
- Lisheng Zhang (ORCID: https://orcid.org/0000-0003-1872-9978)
- Dongping Zheng
- Tianran Sheng (ORCID: https://orcid.org/0000-0003-1831-4377)
- Jiusi Yang
- Kai Du (ORCID: https://orcid.org/0000-0003-0317-990X)
- Weiwei Zhan (ORCID: https://orcid.org/0000-0002-2015-4627)
- Tingting Lu (ORCID: https://orcid.org/0000-0002-2356-2714)
- Peng Qian (ORCID: https://orcid.org/0000-0002-1428-7028)
- Tongtong Zhu (ORCID: https://orcid.org/0000-0002-5481-6836)
- Yuting Ren (ORCID: https://orcid.org/0009-0009-1992-9809)
- Jinxiu Liu
Institutions
- University of Science and Technology of China (CN)
- Fuyang Normal University (CN)
- Biomass Technology Group (Netherlands) (NL)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1021/acs.orglett.5c04010
- Citations
- 3
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 2.81