Limosilactobacillus reuteri in Pediatric Oral Health: A Systematic Review

Background: Limosilactobacillus reuteri (L. reuteri), present in the oral and intestinal microbiota, can colonize the oral cavity through breastfeeding and dairy intake, promoting oral health by balancing the microbiota, inhibiting pathogens, and modulating immune responses. This study aimed to evaluate the preventive role and therapeutic potential of L. reuteri in pediatric oral health. Methods: A literature review was conducted using PubMed, Wiley Library, and the Cochrane Library, supplemented by manual screening, according to PRISMA guidelines and covering the period from January 2011 to 31 December 2024. Results: From 835 records identified, 12 studies met the inclusion criteria. Data shows that L. reuteri strains produce antimicrobial substances that disrupt biofilms and inhibit Streptococcus mutans and other lactobacilli, leading to increased oral pH and improved periodontal indices. The effectiveness of probiotics was found to be strain-specific and transient, with continuous intake and adequate oral hygiene enhancing their ability to colonize the oral cavity. Conclusions: Probiotics show significant potential as therapeutic interventions for controlling cariogenic bacteria and supporting gum health in children. Through mechanisms including bacterial co-aggregation, competitive exclusion, antimicrobial compound synthesis, and immune modulation, probiotics may effectively reduce the risk of tooth decay and gum disease. Their effectiveness depends on the strain, regular intake, proper dosing, good oral hygiene, and suitable delivery, which enhance oral colonization and clinical benefits.