miR-191-5p attenuates TNF-α-induced inflammation in nucleus pulposus cells via targeting EGR1
miR-191-5p enhanced cell viability and migration while concurrently suppressing ECM degradation, apoptosis and inflammatory responses via negative regulation of EGR1, which in turn inhibited the progression of IVDD.
Authors
- Zeyu Yang (ORCID: https://orcid.org/0000-0002-7223-5234)
- Lian Li (ORCID: https://orcid.org/0000-0003-4700-1134)
- M. Cen
- Rubing Lin
Institutions
- Taizhou Municipal Hospital (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Baise University (CN)
- Yantaishan Hospital (CN)
- Shenzhen Children's Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s13018-025-06327-5
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00