In vitro derivation of midbrain dopaminergic neurons from porcine embryonic stem cells in multi-dimensional conditions
. This study presents the first robust platform for generating functionally validated mDA neurons and midbrain-like organoids from porcine stem cells. The findings highlight species-specific signaling dynamics and establish porcine in vitro models as scalable, translational systems for investigating neurodevelopment and disease mechanisms.
Authors
- Hyerin Choi (ORCID: https://orcid.org/0000-0001-6320-456X)
- Byoung Chol Oh (ORCID: https://orcid.org/0000-0003-3337-7739)
- Zheng Haomiao
- Hanyong Jin (ORCID: https://orcid.org/0000-0002-5850-0791)
- Jaehyeok Seo
- Ah‐Young Oh (ORCID: https://orcid.org/0000-0002-3659-6171)
- Dongjin Oh (ORCID: https://orcid.org/0000-0002-4055-4361)
- Jun-Sang Ham (ORCID: https://orcid.org/0000-0003-4966-6631)
- Sang‐Hwan Hyun (ORCID: https://orcid.org/0000-0001-6011-2555)
- Ali Jawad (ORCID: https://orcid.org/0000-0002-9356-9997)
- June Seok Heo (ORCID: https://orcid.org/0000-0002-8482-0617)
Institutions
- Johns Hopkins University (US)
- Chungbuk National University (KR)
- Johns Hopkins Medicine (US)
- Chungbuk National University Hospital (KR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s13287-025-04693-9
- Citations
- 1
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81