Diagnostic challenges and therapeutic strategies for large-cell neuroendocrine carcinoma of extrahepatic bile ducts: A rare case report

This case underscores the aggressive nature of LCNEC of the EHBD and the crucial role of MDT-driven surgical intervention. The rapid recurrence suggests the necessity for postoperative adjuvant therapy; however, standard treatment protocols are lacking due to insufficient evidence from evidence-based medicine, highlighting the need for biomarker-driven strategies. The rarity of these tumors renders standardized management elusive, necessitating global collaboration to refine diagnostic and therapeutic frameworks.