Integrative multi-omics analysis identifies genetically supported druggable targets for inflammatory bowel disease
Our multi-layered omics framework provided genetically anchored evidence for the role of THBS3, RORC, and TNFRSF25 as druggable targets in IBD. The identified candidate drugs offered new avenues for therapeutic intervention. Further clinical validation is warranted to harness these targets for the development of effective IBD treatments.
Authors
- Chang‐Yi Shen
- Yu Song (ORCID: https://orcid.org/0000-0003-0192-9076)
- Can‐Xing Yuan (ORCID: https://orcid.org/0000-0002-8893-8161)
- Shan Zeng (ORCID: https://orcid.org/0000-0002-0988-723X)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-2154-2485)
- Qing Ye (ORCID: https://orcid.org/0000-0002-4436-4581)
- Si‐Chun Gu
Institutions
- Shanghai Mental Health Center (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Genetic Engineering and Biotechnology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1016/j.jgeb.2025.100608
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82