CXCR5-engineered mesenchymal stromal cells home to spleen and mitigate post-sepsis syndrome by preventing secondary infection
Our findings demonstrate that MSC<sup>CXCR5</sup> confers dual-phase protection in sepsis, improving survival during both the initial hyperinflammatory phase and subsequent immunosuppressive period. This comprehensive therapeutic effect stems from MSC<sup>CXCR5</sup>'s ability to preserve B-cell function and prevent secondary infections in septic mice.
Authors
- Xiaomeng Yi
- Lu Zhu (ORCID: https://orcid.org/0000-0001-9013-7147)
- Xiaoran Zhang (ORCID: https://orcid.org/0000-0001-6421-0355)
- Andy Peng Xiang (ORCID: https://orcid.org/0000-0003-3409-5012)
- Minjie Liu
- Yunli Tong (ORCID: https://orcid.org/0009-0001-3743-3403)
- Rui Fang (ORCID: https://orcid.org/0000-0001-6202-8162)
- Zhishan Li (ORCID: https://orcid.org/0000-0003-2211-735X)
- Heshe Li
- Yingying Bao (ORCID: https://orcid.org/0000-0001-5496-5877)
- Tao Wang (ORCID: https://orcid.org/0000-0002-5564-6496)
- Jianqi Feng
- Xiaoyong Chen (ORCID: https://orcid.org/0000-0003-4205-3613)
- Jing Huang (ORCID: https://orcid.org/0000-0003-0948-7954)
- Xiang Sui
- Dandan Zhu (ORCID: https://orcid.org/0000-0003-2296-3994)
- Yuantao Li (ORCID: https://orcid.org/0000-0003-4531-7864)
- Lin Nie (ORCID: https://orcid.org/0009-0008-7788-4576)
- Jiahao Shi (ORCID: https://orcid.org/0009-0001-8663-4228)
- Robert Lin
- Ying Wang (ORCID: https://orcid.org/0000-0002-2571-9367)
Institutions
- Sun Yat-sen University (CN)
- Guangzhou Development Zone Hospital (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s13287-025-04751-2
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Association for Science and Technology
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Sanming Project of Medicine in Shenzhen
- National Key Research and Development Program of China
- National Key Research and Development Program of China Stem Cell and Translational Research
- Special Project for Research and Development in Key areas of Guangdong Province