Establishment of rabbit models of lumbar disc degeneration using three methods monitored via X-ray: a comparative study
These findings confirm that NPA, NPA + PNB, and NPA + AEI are effective techniques for inducing IDD in a rabbit model. Among these, the NPA + PNB method represents one of the best options for achieving a reliable, reproducible, and minimally invasive model, producing consistent and severe degeneration with a high degree of standardization. This technique presents a valuable tool for future research investigating the pathogenesis of IDD and evaluating the efficacy of potential therapeutic strategies.
Authors
- Tong Wu (ORCID: https://orcid.org/0000-0003-1182-9546)
- Xuewen Shi (ORCID: https://orcid.org/0000-0002-3632-2859)
- Jinpeng Lou
- Hao An (ORCID: https://orcid.org/0000-0003-0919-2283)
- Tao Zhang (ORCID: https://orcid.org/0000-0002-0694-5916)
- Wenji Wang (ORCID: https://orcid.org/0000-0003-1662-2130)
- Yun Zheng (ORCID: https://orcid.org/0000-0002-1708-4146)
- Hua Liu (ORCID: https://orcid.org/0000-0002-8591-9205)
- Yunfei Li (ORCID: https://orcid.org/0000-0003-0988-9400)
Institutions
- 117th Hospital of People's Liberation Army (CN)
- People's Liberation Army 401 Hospital (CN)
- Dingxi City People's Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s13018-025-06396-6
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese People’s Liberation Army