Cyclometallated iridium( <scp>iii</scp> ) complexes: ligand-driven selectivity for chemotherapy and photodynamic therapy
This study explores two cyclometallated Ir(III) complex families with distinct therapeutic profiles. Benzothiophene derivatives (1, 2) exhibit potent antiproliferative character in the dark, favoring chemotherapy, while benzothiazole analogs (3 and 4) show high photocytotoxicity, ideal for photodynamic therapy. Photophysical studies and subcellular localization analyses highlight ligand-driven selectivity and the role of organelle targeting in therapeutic outcomes.
Authors
- María Royo‐Cañas (ORCID: https://orcid.org/0000-0003-4915-4839)
- Pilar García‐Orduña (ORCID: https://orcid.org/0000-0002-7063-1292)
- M. Concepción Gimeno (ORCID: https://orcid.org/0000-0003-0553-0695)
- Araceli de Aquino (ORCID: https://orcid.org/0000-0001-9777-3445)
- Vanesa Fernández‐Moreira (ORCID: https://orcid.org/0000-0002-1218-7218)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Chimie ParisTech - PSL (FR)
- Universidad de Zaragoza (ES)
- Université Paris Sciences et Lettres (FR)
- Instituto de Síntesis Química y Catálisis Homogénea (ES)
- Servicio Aragonés de Salud (ES)
- Instituto Aragonés de Ciencias de la Salud (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc04768d
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00