An Fe(II)-catalyzed synthesis of spiro[indoline-3,2'-pyrrolidine] derivatives
A synthetic strategy for the preparation of spiro[indoline-3,2'-pyrrolidine] derivatives has been developed, featuring a two-step sequence consisting of the reaction of 2-arylindoles with α,β-unsaturated ketones, followed by Fe(II)-catalyzed spirocyclization of readily accessible oxime acetates. The method exhibits a broad substrate scope and good functional group tolerance. The synthesized spirocyclic compounds showed no significant antimicrobial activity.
Authors
- Elizaveta V Gradova
- Larisa Yu. Nesterova (ORCID: https://orcid.org/0000-0003-2885-2777)
- Maxim G. Uchuskin (ORCID: https://orcid.org/0000-0001-9008-7610)
- А. Г. Ткаченко (ORCID: https://orcid.org/0000-0002-8631-8583)
- Roman O. Shcherbakov (ORCID: https://orcid.org/0000-0002-6383-5123)
- Elena Y. Mendogralo (ORCID: https://orcid.org/0000-0003-3721-8516)
- Nikita A Ozhegov
Institutions
- Perm State University (RU)
- Institute of Ecology and Genetics of Microorganisms (RU)
Publication Details
- Journal
- Beilstein Journal of Organic Chemistry
- Published
- 2025-11-05
- DOI
- https://doi.org/10.3762/bjoc.21.183
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation