Integrating genetics and transcriptome analyses identify potential biomarkers and immune interactions in metabolic syndrome-related sarcopenia
This research offers compelling proof of a shared genetic architecture and uncovered immune interactions between MetS and sarcopenia. Our unique innovation reveals the comorbidity mechanism of metabolic syndrome and sarcopenia from a genetic perspective. The discovery of pleiotropic genes provided potential targets for intervention in MetS-related sarcopenia.
Authors
- Ning Chang (ORCID: https://orcid.org/0000-0003-2842-7658)
- Xiaoming Wang (ORCID: https://orcid.org/0000-0003-4559-7413)
- Li Xu (ORCID: https://orcid.org/0000-0003-2721-0377)
- Wei Fu (ORCID: https://orcid.org/0000-0001-5998-011X)
- Kaikai Yang
- Rong Xu
Institutions
- Air Force Engineering University (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s12967-025-07191-x
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- National Natural Science Foundation of China