Insights into knee post-traumatic osteoarthritis pathophysiology from the relationship of serum biomarkers to radiographic features in the ADVANCE cohort
This large, unique study suggests different pathological processes underpinning each radiographic feature of PTOA, including predominant unbalanced ECM-catabolism and inflammation contributing to JSN, ECM-catabolism and increased inflammation contributing to osteophyte development and an inflammation-predominant process contributing to subchondral sclerosis.
Authors
- Ana M. Valdes (ORCID: https://orcid.org/0000-0003-1141-4471)
- Stefan Kluzek (ORCID: https://orcid.org/0000-0002-0696-7541)
- Oliver O’Sullivan (ORCID: https://orcid.org/0000-0002-9184-4713)
- Fraje Watson
- Anthony M. J. Bull (ORCID: https://orcid.org/0000-0002-4473-8264)
- Alexander N. Bennett (ORCID: https://orcid.org/0000-0003-2985-5304)
Institutions
- University of Nottingham (GB)
- King's College London (GB)
- Arthritis UK (GB)
- Nottingham Biomedical Research Centre (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s13075-025-03648-y
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00