Visible-light-induced radical trifluoromethylation/cyclization of alkynes: synthesis of CF <sub>3</sub> -containing dioxodibenzothiazepines
A simple and metal-free photoinduced radical trifluoromethylation/cyclization reaction of alkynes with readily preparable and air-stable trifluoromethyl thianthrenium triflate (TT-CF<sub>3</sub><sup>+</sup>OTf<sup>-</sup>) as the trifluoromethyl source has been developed. This transformation can be carried out without using metal catalysts and strong oxidants, providing an avenue to construct a series of potential pharmaceutically valuable trifluoromethylated dioxodibenzothiazepines under mild conditions. This protocol offers a green strategy for the synthesis of useful CF<sub>3</sub>-containing seven-membered N-heterocycles.
Authors
- Yangjie Wu (ORCID: https://orcid.org/0000-0002-0134-0870)
- Yusheng Wu (ORCID: https://orcid.org/0000-0001-7023-9541)
- Dapeng Zou
- Yang Geng (ORCID: https://orcid.org/0000-0001-6865-4156)
- Xiaoyu Chen (ORCID: https://orcid.org/0000-0003-3561-9746)
- Wu Zhiyong (ORCID: https://orcid.org/0000-0001-9333-5130)
- Pan Liu (ORCID: https://orcid.org/0009-0002-8459-2922)
Institutions
- Zhengzhou University (CN)
- Tyvak (United States) (US)
- Zhengzhou Railway Vocational & Technical College (CN)
- Henan Agricultural University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01520k
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00