Syntaphilin loss enhances mitochondrial axonal transport and neuromuscular junction formation in a human stem cell derived neuromuscular assembloid model
This proof-of-concept study demonstrated that enhancing mitochondrial mobility could provide a therapeutic target to prevent NMJ degeneration.
Authors
- Esra Özkan (ORCID: https://orcid.org/0000-0001-6503-8665)
- David Story (ORCID: https://orcid.org/0000-0002-6479-1310)
- Vidya Ramesh (ORCID: https://orcid.org/0000-0003-0375-7562)
- Bhuvaneish Thangaraj Selvaraj (ORCID: https://orcid.org/0000-0001-7299-0910)
- Nhan T. Pham (ORCID: https://orcid.org/0000-0003-1620-2910)
- Andrea Salzinger (ORCID: https://orcid.org/0000-0002-8100-8236)
- Siddharthan Chandran (ORCID: https://orcid.org/0000-0001-6827-1593)
- Jyoti Nanda (ORCID: https://orcid.org/0000-0002-3547-6266)
- Karen Burr
Institutions
- MRC Centre for Regenerative Medicine (GB)
- UK Dementia Research Institute (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-11-05
- DOI
- https://doi.org/10.1186/s10020-025-01319-x
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Humane Research Trust
- European Commission
- Universiteit Leiden
- Leids Universitair Medisch Centrum
- UK Dementia Research Institute
- Medical Research Council