Iron-Catalyzed C(sp <sup>3</sup> )–H Amination Enabled by Visible-Light β-Homolysis
In this study, we developed a visible light-mediated C(sp<sup>3</sup>)-H amination strategy enabled by ligand-to-metal charge transfer (LMCT) and iron catalysis. The inexpensive Fe(NO<sub>3</sub>)<sub>3</sub>·9H<sub>2</sub>O affords a photoactive iron complex upon coordination with N-heteroaryl substrates, and the complex undergoes LMCT-induced β-homolysis to produce a high-valent Fe(IV)═O species. The Fe(IV)═O species promotes alkyl radical formation, enabling efficient C(sp<sup>3</sup>)-N bond construction. The reaction operates under mild conditions with broad functional group tolerance and excellent scalability, providing a practical platform for C(sp<sup>3</sup>)-H amination.
Authors
- Xu-Gang Zhang
- Peng‐Fei Xu (ORCID: https://orcid.org/0000-0002-5746-758X)
- Yi Zhao
- Haowen Jiang (ORCID: https://orcid.org/0000-0003-4419-7645)
- Xiu‐Qin Hu
- Huan-Huan Zhao (ORCID: https://orcid.org/0009-0003-1361-4482)
Institutions
- Xinjiang Entry-Exit Inspection and Quarantine Bureau (CN)
- State Key Laboratory of Chemical Engineering (CN)
- Gansu Provincial Center for Disease Control and Prevention (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1021/acs.orglett.5c03480
- Citations
- 1
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94