Silver-catalyzed diastereoselective cascade radical cyclization of CF <sub>3</sub> -alkenyl quinolones with diarylphosphine oxides
A silver catalyzed phosphorus radical promoted cascade cyclization of quinolone derived unactivated olefins is described to access dual-functionalized dihydrophenanthridinones bearing phosphoryl and CF<sub>3</sub>-carbinol groups. The reaction achieves concurrent C-P and C-C bond formation in one step, providing excellent yields and high diastereoselectivity (>20 : 1). The CF<sub>3</sub> group exerts a strong steric effect, which helps achieve remarkable diastereoselectivity.
Authors
- Nagender Punna (ORCID: https://orcid.org/0000-0003-2761-6078)
- Jaggaraju Prudhviraj
- Chavakula Nagababu
- Rami Sateesh
- Krishna Swaroop Desireddy
Institutions
- Indian Institute of Chemical Technology (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01505g
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00