Postoperative Lymph Is a Proximal Source of ctDNA for Detection of Recurrence in HPV-Independent Head and Neck Cancer
Postoperative lymph is a novel, proximal, and early source of MRD with the potential to introduce more precision into adjuvant therapy decision-making and improve outcomes, especially for patients with intermediate-risk human papillomavirus-independent head and neck squamous cell carcinoma.
Authors
- Zhuosheng Gu (ORCID: https://orcid.org/0009-0007-6395-2665)
- Taylor J. Jensen (ORCID: https://orcid.org/0000-0002-7206-7656)
- Maciej Pacula (ORCID: https://orcid.org/0009-0006-6376-3568)
- Heath Devin Skinner (ORCID: https://orcid.org/0000-0003-1836-151X)
- Ellen L. Verner (ORCID: https://orcid.org/0000-0002-0208-4784)
- Rebecca D. Chernock (ORCID: https://orcid.org/0000-0001-6253-0478)
- Sidharth V. Puram (ORCID: https://orcid.org/0000-0003-3543-889X)
- Lucien Khalil (ORCID: https://orcid.org/0000-0002-5084-9112)
- Peter K. Harris (ORCID: https://orcid.org/0000-0003-1557-1722)
- Seka Lazare (ORCID: https://orcid.org/0000-0002-6519-4454)
- Zhongping Xu (ORCID: https://orcid.org/0009-0000-2307-5580)
- Dan Paul Zandberg (ORCID: https://orcid.org/0000-0002-1002-8301)
- Ricardo J. Ramirez (ORCID: https://orcid.org/0000-0002-6483-5109)
- Joshua D. Smith (ORCID: https://orcid.org/0000-0002-2076-7589)
- Megan Rivera (ORCID: https://orcid.org/0009-0001-7440-5452)
- Amy Greer (ORCID: https://orcid.org/0009-0001-8809-3648)
- Andrew Georgiadis (ORCID: https://orcid.org/0009-0007-9121-9778)
- Marra S. Francis (ORCID: https://orcid.org/0000-0003-1844-5633)
- Raja R. Seethala (ORCID: https://orcid.org/0000-0003-3617-075X)
- Adam Benson (ORCID: https://orcid.org/0009-0002-5572-2222)
- Douglas R. Adkins (ORCID: https://orcid.org/0000-0003-3207-8227)
- Damion Whitfield (ORCID: https://orcid.org/0009-0001-9708-0582)
- Matthew E. Spector (ORCID: https://orcid.org/0000-0001-7646-6075)
- Noah Earland (ORCID: https://orcid.org/0000-0003-0170-407X)
- Aadel A. Chaudhuri (ORCID: https://orcid.org/0000-0003-3115-3061)
- Wade L. Thorstad (ORCID: https://orcid.org/0000-0002-2757-0543)
- Benjamin M. Wahle (ORCID: https://orcid.org/0000-0001-8806-2190)
- Wendy Winckler (ORCID: https://orcid.org/0009-0008-9893-9652)
- Shakti Ramkissoon (ORCID: https://orcid.org/0000-0003-3531-2912)
- Mark Sausen (ORCID: https://orcid.org/0000-0002-2916-5269)
- Robert L. Ferris (ORCID: https://orcid.org/0000-0001-6605-2071)
- Sophie P. Gerndt (ORCID: https://orcid.org/0000-0001-9918-453X)
- Jose P. Zevallos (ORCID: https://orcid.org/0009-0003-2442-6014)
- Ashley Tellis (ORCID: https://orcid.org/0009-0009-2122-0540)
- M. Harmon (ORCID: https://orcid.org/0009-0006-6243-0884)
Institutions
- University of North Carolina at Chapel Hill (US)
- Allegheny Health Network (US)
- Mayo Clinic (US)
- University of Pittsburgh (US)
- Washington University in St. Louis (US)
- University of Missouri–St. Louis (US)
- LabCorp (United States) (US)
- Mercy Hospital Springfield (US)
- UPMC Health System (US)
- Cancer Clinic (US)
- Axios Biosciences (United States) (US)
- Mayo Clinic in Arizona (US)
- UPMC Hillman Cancer Center (US)
- University of Pittsburgh Medical Center (US)
- Mayo Clinic in Florida (US)
- Wake Forest University (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-1221
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00