Induction of apoptosis and growth inhibition by silodosin and abiraterone acetate in PC-3 human prostate cancer cells
Silodosin exhibits potent effects in reducing cell viability and promoting apoptosis in androgen-insensitive prostate cancer cells, comparable to AA. When combined, both agents demonstrate synergistic effects with reduced dosing requirements. These findings support further investigation of silodosin as a potential therapeutic in mCRPC.
Authors
- Zakaria Aulia Rahman (ORCID: https://orcid.org/0000-0002-2442-0996)
- Furqan Hidayatullah (ORCID: https://orcid.org/0000-0002-7479-2704)
- Lukman Hakim (ORCID: https://orcid.org/0000-0003-1518-8010)
- Chi‐Fai Ng (ORCID: https://orcid.org/0000-0002-1723-9646)
Institutions
- Sepuluh Nopember Institute of Technology (ID)
- Chinese University of Hong Kong (HK)
- Universitas Airlangga (ID)
- Universitas Nusa Bangsa (ID)
Publication Details
- Journal
- Investigative and Clinical Urology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.4111/icu.20250310
- Primary Topic
- Silymarin and Mushroom Poisoning
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitas Brawijaya